Yes, niacinamide does not produce the flush. However, while niacinamide may have some (mild) benefit in boosting NAD+ levels, it does not offer the benefits that nicotinic acid has on LDL and HDL profiles.
There is the option of "No-Flush Niacin" (inositol hexaniacinate), which releases niconitic acid slowly. This (mainly) avoids the flush, although the benefits are not as pronounced either.
i have been cycling my vit b supplements for many years now as i often experience negative effects like flushing, nausea and gastro upset… i do find sublingual delivery to be the gentlest way to take it but even that sometimes gives me issues… any other suggestions to over come this?
So the benefits of niacin (in the nicotinic acid form) cannot be separated from its effects on the prostaglandins... which induces flushing given the 'right' conditions. So the one thing here is to look at the conditions. Which, to over-simplify, comes down to identifying what is driving/permitting excessive inflammation. There is naturally no one-size-fits-all here, as this could relate to triggers (environmental (mould/allergies), chronic infection, dysbiosis, oxidative stress, etc) or to poor regulation (cortisol, vitamin D, glutathione, mast cells, etc), or a bit of both. This is where some suitable functional tests can be a great starting point (provided you have someone who can help you make use of these, of course!).
Excellent post.... thank you for sharing this detox info. :)
I always understood that to avoid the niacin flush you could take niacinamide?
Yes, niacinamide does not produce the flush. However, while niacinamide may have some (mild) benefit in boosting NAD+ levels, it does not offer the benefits that nicotinic acid has on LDL and HDL profiles.
There is the option of "No-Flush Niacin" (inositol hexaniacinate), which releases niconitic acid slowly. This (mainly) avoids the flush, although the benefits are not as pronounced either.
thank you so much for this info!
i have been cycling my vit b supplements for many years now as i often experience negative effects like flushing, nausea and gastro upset… i do find sublingual delivery to be the gentlest way to take it but even that sometimes gives me issues… any other suggestions to over come this?
So the benefits of niacin (in the nicotinic acid form) cannot be separated from its effects on the prostaglandins... which induces flushing given the 'right' conditions. So the one thing here is to look at the conditions. Which, to over-simplify, comes down to identifying what is driving/permitting excessive inflammation. There is naturally no one-size-fits-all here, as this could relate to triggers (environmental (mould/allergies), chronic infection, dysbiosis, oxidative stress, etc) or to poor regulation (cortisol, vitamin D, glutathione, mast cells, etc), or a bit of both. This is where some suitable functional tests can be a great starting point (provided you have someone who can help you make use of these, of course!).
thank you for this. i suspected something along those lines